The gang forces an over-worked Fred to relax and take time off from mysteries at Daphne's family's beach house. Unfortunately, when a walking shark attacks the ritzy beach community, the gang is forced to solve the mystery.
The gang rushes Scooby to an animal hospital when he suddenly falls ill. But things go from bad to worse when they discover the Gothic, old hospital is also home to a rampaging werewolf!
The gang heads to the Velma's beloved authentic Renaissance Faire, where they must find a way to infiltrate the royal feast in order to stop an evil court jester from ending the king's reign.
Finally fed up with monsters and mayhem, Shaggy and Scooby decide to quit the gang and train their replacements in one on-the-job training session, unraveling the mystery of a vampire that's terrorizing a small town.
After a Giant Houndbeast attacks an elite dog show, the gang goes undercover and enters Scooby in the show in order to solve the mystery.
Unhappy about a mystery-free, three-day, cross-country train trip with the gang, Fred is pleasantly surprised to discover a monster mystery on board.
The gang goes trick or treating on Halloween night but Velma seems to think that Halloween is a disrespect to history while Daphne, Shaggy and Scooby have the opposite opinion.
On a trip to Japan to visit Velma's friend, the gang comes face to face with the ancient crab monster, Kaniaku, and attempts to solve a 700 year-old mystery. Meanwhile, Daphne accidentally becomes a viral media sensation!
When the ghost of a small town's founder returns to scare off mayoral candidates, the gang decides to run Velma as mayor to bait the ghost. They quickly discover, however, that Velma lacks the skills to make her a politician!
The gang travels to Britain in 1843-ish and runs into Scrooge who claims he was attacked by the ghost of his partner Jacob Marley and that three more ghosts are coming. The gang agrees to solve the mystery.
A very bad parking choice on Fred's part leads the gang to an asteroid mining base in outer space where an alien virus appears to be infecting the crew one by one, turning them into evil skull-headed aliens.
To escape a snowstorm, the gang checks into a creepy, massive hotel run by a man very strict about the hotel rules established by his deceased mother. The gang soon discovers the penalty for breaking the hotel rules.
The gang tours an old Hollywood Studio, but they soon uncover a mystery concerning the ghost of a silent film comedy star who has returned to make sure his recently discovered final film is never seen!
Fred lives out his childhood dream of being a stage magician as he and the gang go uncover at a private magic club being terrorized by a mutant Rabbit monster!
The gang travels back to Ancient Greece, where they play unique roles in a Greek Mystery involving the mythological spider woman, Arachne, and her attempts to disrupt the royal wedding that would unite two great cities!
Shaggy's friend Amelia invites Shaggy and the gang to a party. But Shaggy discovers that Amelia has become a goth. Shaggy starts to feel bad that he hasn't changed at all so he decides he too will become a goth.
The gang gets caught up in international espionage and intrigue when they cross paths with British secret agent, Jenny Vex, and must help her complete her mission of stopping an evil mercenary, Minus from killing breakfast.
Fred's worst nightmare comes true when an evil spirit possesses the Mystery Machine and turns his beloved van into an unrelenting monster out to destroy him and the gang before they can solve the mystery.
Daphne brings the gang to a fancy Ice Hotel co-owned by her family where a new exhibit of ice age artifacts is opening. Things heat up, however, when a frozen Ice Man thaws out and goes on a rampage inside the hotel.
The gang heads to Shaggy's beloved grandmother's Florida retirement home, where they learn a crazed Ape Man has been frightening the elderly residents.
Scooby runs into an old kennel mate Axel who is a highly trained Police dog who thinks mystery of the Junk yard monster is too big a case for the gang.
When a video game company tries to buy an old algorithm from Velma and convince her to work for them in San Francisco, the gang becomes joins in the mystery of a game villain who has seemingly come to life, the Ghost Chef.
The gang goes to Salem, Massachusetts for a historical festival, only to discover history repeating itself as a demon has been set loose on the town, summoned by a witch as revenge for the infamous Salem Witch Trials.
Fred and the gang are called to help with a mystery involving a figure from Fred's past, Professor Huh? Fred discovers Rose, with whom he learned mystery solving until they had a falling out, has also arrived with her gang.
The gang goes on the run after they are believed to be helping the mysterious Professor Huh?
Shaggy drags the gang to an arcade where he's determined to finally collect enough tickets to win the prize he's wanted since he was a boy. Then, Fred comes face to face with his longstanding nemesis Captain Cutler.
On a trip to Japan to visit Velma's friend, the gang comes face to face with the ancient crab monster, Kaniaku, and attempts to solve a 700 year-old mystery. Meanwhile, Daphne accidentally becomes a viral media sensation!
